According to security sources, the blast occurred outside the door of a religious seminary which was located in Kalaya, a town in Orakzai agency.
“Three children were among those killed in the blast,” sources added.
“The remote-controlled bomb was attached to a motorcycle,” security sources said, adding “People were in the market buying warm clothes when the bomb went off.”
The injured were shifted to a hospital for treatment, authorities added.
The area has been completely sealed off and investigation into the incident is under way.
This is not the first time the area has come under attack.
In 2011, 30 people including 10 cops, were killed and over 50 injured when a suicide bomber rammed his explosive-laden double cabin van into the building of the Communication and Works Department.
Human Rights Minister Shireen Mazaro condemned the attack and said, “we must ensure greater security for our tribal areas especially protection of our people.”