Juffali, 27, will drive for defending champions Double R Racing alongside Louis Foster and Sebastian Alvarez.
She made her competitive racing debut in October 2018 – just months after her country lifted a ban on female drivers.
“It’s such a great thing for me to do and represent my country,” she said.
“Brands Hatch is the heart of motorsport,” Jeddah-born Juffali added.
Saudi Arabia issued driving licences to women for the first time in decades in June 2018, as it lifted its ban.
Within five months, Juffali was competing in two-seater racing and has now progressed to single-seater racing.
“It’s going to be a tough year in such a competitive championship, but I’m ready for the challenge,” she said.