Ahmed Shehzad and Dwayne Bravo concluded the chase in the 19th over of the game, in an innings initially built by Shane Watson and Rilee Rossouw.
Shehzad scored unbeaten 32 runs in the innings.
Multan Sultans once again failed to fly high in their batting innings courtesy three wickets each by Tanvir and Darren Bravo in respective brilliant bowling spells.
Muhammad Nawaz picked two wickets while Muhamad Hasnain bagged one to assist the pace attack, in restricting Sultans to 121.
Johnson Charles remained the only key resister for Sultans with his 46 off 36 runs knock with five boundaries and a six, to prevent a complete decimation of Sultans.
The next in line was skipper Shoaib Malik with his 21 off 24.
Gladiators drew the first blood for Multan Sultans with the wicket of James Vince during the powerplay overs in the second fixture of the day at the Dubai International Stadium.
Nawaz got the first wicket for Gladiators in his very first over.