According to initial reports, the bomb was planted in a motorcycle parked along the road which went off as soon as the vehicle of the security personnel approached it.
The security personnel were on their way to Jani Khel.
Security forces have thrown a cordon around the area while rescue services have also reached the scene.
Last month, two security personnel suffered minor wounds when their vehicle was targeted using two improvised explosive devices (IEDs) in the Shorko area of Lower Kurram Agency.
The vehicle was carrying supplies for a check-post in Kurram Agency.