Rescue officials said the vehicle of DSP Hameedullah Dasti was attacked by unidentified personnel on Samungli Road.
The DSP remained unhurt but two police officials accompanying him were killed in the attack.
Sources said law enforcement agencies and rescue teams reached the site of the incident after the attack and launched a search and rescue operation.
Police and security officials are often targetted in the Balochistan capital.
Four security personnel were martyred on Feb 14 when they were attacked near the city’s Sariab Road area. Police said unidentified attackers, riding a motorcycle, targetted a motorcycle patrol of the Frontier Corps (FC) while it was on routine duty along a railway track.
On January 28, a policeman was killed in Quetta’s Hazarganji area in a targetted attack while on January 18, two Balochistan Constabulary officials were killed in Quetta.
Similarly, a police constable was shot dead by unidentified attackers on the city’s Raisani Road on January 16.
A day earlier, on Jan 15, five Pakistan Army soldiers were killed in Kech, Balochistan when their vehicle turned turtle after it was fired at.
On Jan 9, four Balochistan Constabulary personnel were among six killed in a suicide attack near the Balochistan Assembly.
Meanwhile, on Jan 2, at least five people, including two FC personnel, were injured as a result of a gun and bomb attack on a check post in the Baleli area of the provincial capital, said security sources.